Manuel Tironi and Sarah Kelly draw attention to the ways in which Indigenous communities in Chile are leveraging Territorial Control to prevent the spread of Covid-19 for the “Covid-19 and the Social Sciences” series. Rather than relying on the logics of epidemiology to support these preventive actions, communities are appealing to the logics of sovereignty. While cautious about the temptation to draw simplistic and extractive “lessons learned” for Disaster Risk Reduction from the actions of the Mapuche and other Indigenous peoples, the authors describe how the lessons to be learned are about the need to decolonize disaster response, and to acknowledge the deep histories and shared knowledge that can provide communities with the resources to make effective public health and safety decisions for their people.